32 Comments
Dec 31, 2023Liked by Remnant MD

So here is something interesting for you. I come from a long lived family, my grandpa was the youngest who died just before his 90th birthday, but he had developed diabetes Late in life. Everyone else has lived to mid 90s at least. My mom is 88, my dad 90. I’m 55. My dads cholesterol, combined, is under 100. It’s so low that he is supposed to be taking meds to raise it but he can’t tolerate the, so he doesn’t. However, he eats SO MUCH fat, like a 1/4” thick on a roll at dinner. He goes through a tub of butter at least once a week, and that’s only one of his fat sources. He hates ‘bird’ so eats beef and pork almost exclusively. I won’t even go into the amount of butter and sour cream he puts on a potato, you get the picture. My dad is mentally sharp as a tack (he’s awesome).

Then there’s me. I have always exercised multiple times a week, I am careful about my diet but I don’t do keto or anything,just try to get whole foods and complex carbs, lots of fruits and veg, lean meats, etc. I track what 8 eat and focus on getting enough protein and fiber. My weight is great. (Upper 130s at 5’7”). My cholesterol is ‘high’. Specifically, my total runs in the 230s, last check LDL was 146, HDL 79, and triglycerides 42. So my triglyceride to HDL ratio is .53. When I had the cardiac IQ test done, my small particle LDL was around 1900. So definitely ‘too high’. I don’t know my moms specific numbers, but her cholesterol has a

Expand full comment

Is there a more recent study you would recommend on statins causing diabetes than the 2010 study you pointed out? Excellent article by the way-thank you

Expand full comment
Dec 9, 2023Liked by Remnant MD

Great points. I’ve seen a lot of issues regarding the need to rethink cholesterol management.

Expand full comment
Dec 6, 2023Liked by Remnant MD

Years ago, One of my Drs made me swear never to take a statin & get my numbers down naturally

Expand full comment

Is there any correlation between long term statin usage 30+ years

and Alzheimer’s/ degenerative dementia?

Expand full comment

In 1850, heart disease was the 25th cause of death, on par with accidental drowning.

Today a 40 yr old has as much of a chance of dying from a heart attack as a 70 yr old in 1970.

Weren't statins supposed to help?

https://romanshapoval.substack.com/p/why-heart-disease-is-an-electrical

Expand full comment
Dec 4, 2023Liked by Remnant MD

I am a retired surgical nurse with open heart experience. Being highly suspicious of the benefit of statins , since my father went into kidney failure after being prescribed statins back in the 80’s, I did my own study with patients in our open heart program. The result was that very few of our patients had high cholesterol or LDL. They were usually smokers or diabetics and some over weight. I am a healthy lean and active, tennis, bike riding female who developed pre diabetes while on Crestor 10 mg. I stopped the Crestor and started taking Krill Oil , which seemed to be bringing down numbers but then I developed Atrial fib so stopped the Krill Oil. I recently read an article on substack that indicated Omega 3’s may be causing new Afib occurrences. My take on this is that better living, better health is not thru chemistry.

Expand full comment

"LDL levels can be elevated in individuals with low thyroid activity because T3 helps sensitize the LDL receptor on the cell membrane. Lower active T3 will cause an inability of the LDL particles to dock on the cell membrane drop the cholesterol and fat soluble nutrients into the cell. So the body adapts and increases the amount of overall LDL cholesterol similar to how insulin goes up in response to insulin resistance." -- Dr David Jockers

Expand full comment

My Medicare Advantage HMO plan mandates two exams per year, which I call the "Are you still alive?" visits. My cholesterol is always a bit north of 200, which causes my doctor great angst. This in spite of the fact that I am probably one of very few "old" patients she has (I am 76) that have no prescriptions, no metabolic diseases, and start each day with 100 push-ups and a 5k walk. Dr. Robert Lustig says that the triglyceride to HDL ratio is a predictor of heart disease, and a value of 1.5 means "you will live forever". I'm at 1.6, and proceeding on the assumption that I have ¼ of my life yet to be lived. I'm a firm believer in Dr. Peter Attia's concept of "Medicine 3.0" in his book 'Outlive', which is based on your root cause approach.

Expand full comment
Dec 3, 2023Liked by Remnant MD

"...But, what about LDL cholesterol..."

Except there is no such thing.

LDL merely transports cholesterol

And cholesterol is cholesterol...

Expand full comment
Dec 3, 2023Liked by Remnant MD

Thanks for this.

Want to get my mom off statins who's been on them since a bogus "high cho" result 2 or 3 decades ago (when she was in early thirties!!).

But apparently doctor said that once you've been on them for so long you "shouldn't get off them."

Any value to this concept at all? Or can I encourage her to throw them out

Expand full comment
Dec 3, 2023Liked by Remnant MD

Thank you for this article. In people who have already demonstrated coronary artery disease and or have suffered a myocardial infarction statins do however have an overall mortality lowering effect albeit small

Expand full comment
Dec 3, 2023Liked by Remnant MD

Thank you for this! Any further thoughts on elevated LDL levels ever since being a healthy, slender, active 20-year old with no apparent "inflammatory stress, tissue damage or some other cause of elevated cell turnover", a familial tendency for elevated LDL, homozygous for APOE4 and a malignancy that (according to all published papers read on the topic) primarily utilizes fat, and where elevated LDL is seen among most patients? Seems like this would be an outlier case where lipophilic statins would have a place, owing in part to their LDL lowering effect, but also due to their other relevant effects (Jiang, W., Hu, JW., He, XR. et al. Statins: a repurposed drug to fight cancer. J Exp Clin Cancer Res 40, 241 (2021). https://doi.org/10.1186/s13046-021-02041-2)

Expand full comment

How can one tease out the effect of years of low dose statins on T2D & someone’s A1C? I know 2 guys in their 70’s who are battling their T2D diagnoses. They are both lean and active. Their docs juggle which diabetes drugs they try. Other than stopping the statin (which they are loath to do because “the doctor says ...”), and observing what happens over 90 days, are there any studies or references that can help to under if the statins are an underlying cause of their high A1C?

Expand full comment
Dec 3, 2023Liked by Remnant MD

I agree.. Thanks for posting this!

Expand full comment