I have shared my thoughts on tumor growth and cancer without a unifying framework. If you have ever had the nagging thought that the current cancer paradigm is incomplete, this is for you.
I like your diffuse-but-converging reconceptualization... fits nicely with the metabolic explanation of cancer as arising from chronic cellular dysfunction.
I believe there are other important factors, such as food, environmental toxins, and stress. Exercise, sleep, and emotional/spiritual well-being most likely also play a role. Thus, the general and overall health of the body could be the unseen protection, or vulnerability for cancer growth! What do you think?
2000 1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70. doi: 10.1016/s0092-8674(00)81683-9. PMID: 10647931.
2011 2. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. PMID: 21376230.
2014 3. Dejeans, N et al. 2014. Addicted to secrete – novel concepts and targets in cancer therapy Trends in Molecular Medicine 20:242-250
2017 4. Fouad YA, Aanei C. Revisiting the hallmarks of cancer. Am J Cancer Res. 2017 May 1;7(5):1016-1036. PMID: 28560055; PMCID: PMC5446472.
2017 5. Baker S, Ali I, Silins I, Pyysalo S, Guo Y, Högberg J, Stenius U, Korhonen A. Cancer Hallmarks Analytics Tool (CHAT): a text mining approach to organize and evaluate scientific literature on cancer. Bioinformatics. 2017 Dec 15;33(24):3973-3981. doi: 10.1093/bioinformatics/btx454. PMID: 29036271; PMCID: PMC5860084.
2020. 6. Meirson T, Gil-Henn H, Samson AO. Invasion and metastasis: the elusive hallmark of cancer. Oncogene. 2020 Feb;39(9):2024-2026. doi: 10.1038/s41388-019-1110-1. Epub 2019 Nov 19. PMID: 31745295.
2020. 7. MacCarthy-Morrogh L, Martin P. The hallmarks of cancer are also the hallmarks of wound healing. Sci Signal. 2020 Sep 8;13(648):eaay8690. doi: 10.1126/scisignal.aay8690. PMID: 32900881.
2020. 8. Rassy E, Assi T, Pavlidis N. Exploring the biological hallmarks of cancer of unknown primary: where do we stand today? Br J Cancer. 2020 Apr;122(8):1124-1132. doi: 10.1038/s41416-019-0723-z. Epub 2020 Feb 11. PMID: 32042068; PMCID: PMC7156745.
2021 9. Senga SS, Grose RP. Hallmarks of cancer-the new testament. Open Biol. 2021 Jan;11(1):200358. doi: 10.1098/rsob.200358. Epub 2021 Jan 20. PMID: 33465324; PMCID: PMC7881179.
2021 10. Somarelli JA. The Hallmarks of Cancer as Ecologically Driven Phenotypes. Front Ecol Evol. 2021 Apr;9:661583. doi: 10.3389/fevo.2021.661583. Epub 2021 Apr 28. PMID: 34703824; PMCID: PMC8544241.
2022 11. Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022 Jan;12(1):31-46. doi: 10.1158/2159-8290.CD-21-1059. PMID: 35022204.
I’ll also eagerly await the next installment before fully commenting other than to ask if you are going to address Warburg and the metabolic theory of cancer?
Obviously waiting for the next instalment but (!) have you read The Cancer Code by Jason Fung which proposes the theory that cancer cells are basically a type of reverse evolution ( to behaving the way single celled organisms would). I can’t remember anymore details at the moment but it explained a lot.
Interesting thought about cells switching behaviors as a group emergence.
A very old neurosurgeon told me a story about a glioblastoma clinical trial that he was involved in. He managed to get one of his patients enrolled -- a teenager with an advanced case. The tumor disappeared. People enrolled in that trial had their tumors evaporate - it was an amazing cure. The scientists behind the trial (I believe it was in Boston) of course wanted to bring this cure to market, but the large pharma who owned this special recipe did a cost-benefit calculation and determined that the price would be too high and the (financial) rewards too few to make it worthwhile.
So rather than publicizing this magic recipe for the whole world to benefit from, they simply didn't proceed with bringing it to market.
As for the teenager who was miraculously cured, he got hit by a car a few years later and died. So I guess he had his timeline pretty set in stone.
This neurosurgeon spent the last years of his life draining his own ascites - advanced liver failure - and continued to serve patients until the day of his death.
I like your diffuse-but-converging reconceptualization... fits nicely with the metabolic explanation of cancer as arising from chronic cellular dysfunction.
I believe there are other important factors, such as food, environmental toxins, and stress. Exercise, sleep, and emotional/spiritual well-being most likely also play a role. Thus, the general and overall health of the body could be the unseen protection, or vulnerability for cancer growth! What do you think?
This course may be of interest to you
IPAK-EDU Biology of Cancer Unit Links
Units 1 & 2
Course Overview & The Genetics of Cancer
https://vimeo.com/749800911
no password
Biology of Cancer Unit 3 - Environmental Factors and GxE
A. Overview and GxE
https://vimeo.com/752355473
B. Carcinogens
https://vimeo.com/640106258
Unit 3
The Hallmarks of Cancer
Hanahan & Weinberg 2000
https://vimeo.com/754958744
Unit 4
Hallmarks of Cancer: The Next Generation
https://vimeo.com/757387394
Unit 5
Hanahan & Weinberg 2011 - Hallmarks of Cancer, The Next Generation
https://vimeo.com/757387394
Unit 6
Hallmarks Revisited and Addicted to Secretion
https://vimeo.com/759938948
Unit 7
Metastasis in Depth
https://vimeo.com/764372907
Unit 8
Hallmarks of Cancer and Wound Healing
https://vimeo.com/766705915
No password
Unit 9
Hallmarks of Cancer of Unknown Primary
https://vimeo.com/769254965
Unit 10
Hallmarks of Cancer - The New Testament
https://vimeo.com/771821607
Unit 11
The Hallmarks of Cancer as Ecologically Driven Phenotypes
https://vimeo.com/776851002
Unit 12
Breast Cancer
https://vimeo.com/790640369
Unit 13
Lung Cancer
https://vimeo.com/792822032
Unit 14
Prostate Cancer
https://vimeo.com/795085255
Unit 15
Colon and Colorectal Cancer
https://vimeo.com/797196736
Unit 16
Pancreatic Cancer
https://vimeo.com/801431175
Unit 17
Gastric Cancer
https://vimeo.com/804042106
Unit 18
Cancers of the Blood
https://vimeo.com/810742942
COMING SOON:
Unit 19
Skin Cancers
Unit 20
Cancers of the Brain and CNS
Readings
2000 1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70. doi: 10.1016/s0092-8674(00)81683-9. PMID: 10647931.
2011 2. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. PMID: 21376230.
2014 3. Dejeans, N et al. 2014. Addicted to secrete – novel concepts and targets in cancer therapy Trends in Molecular Medicine 20:242-250
2017 4. Fouad YA, Aanei C. Revisiting the hallmarks of cancer. Am J Cancer Res. 2017 May 1;7(5):1016-1036. PMID: 28560055; PMCID: PMC5446472.
2017 5. Baker S, Ali I, Silins I, Pyysalo S, Guo Y, Högberg J, Stenius U, Korhonen A. Cancer Hallmarks Analytics Tool (CHAT): a text mining approach to organize and evaluate scientific literature on cancer. Bioinformatics. 2017 Dec 15;33(24):3973-3981. doi: 10.1093/bioinformatics/btx454. PMID: 29036271; PMCID: PMC5860084.
2020. 6. Meirson T, Gil-Henn H, Samson AO. Invasion and metastasis: the elusive hallmark of cancer. Oncogene. 2020 Feb;39(9):2024-2026. doi: 10.1038/s41388-019-1110-1. Epub 2019 Nov 19. PMID: 31745295.
2020. 7. MacCarthy-Morrogh L, Martin P. The hallmarks of cancer are also the hallmarks of wound healing. Sci Signal. 2020 Sep 8;13(648):eaay8690. doi: 10.1126/scisignal.aay8690. PMID: 32900881.
2020. 8. Rassy E, Assi T, Pavlidis N. Exploring the biological hallmarks of cancer of unknown primary: where do we stand today? Br J Cancer. 2020 Apr;122(8):1124-1132. doi: 10.1038/s41416-019-0723-z. Epub 2020 Feb 11. PMID: 32042068; PMCID: PMC7156745.
2021 9. Senga SS, Grose RP. Hallmarks of cancer-the new testament. Open Biol. 2021 Jan;11(1):200358. doi: 10.1098/rsob.200358. Epub 2021 Jan 20. PMID: 33465324; PMCID: PMC7881179.
2021 10. Somarelli JA. The Hallmarks of Cancer as Ecologically Driven Phenotypes. Front Ecol Evol. 2021 Apr;9:661583. doi: 10.3389/fevo.2021.661583. Epub 2021 Apr 28. PMID: 34703824; PMCID: PMC8544241.
2022 11. Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022 Jan;12(1):31-46. doi: 10.1158/2159-8290.CD-21-1059. PMID: 35022204.
Great perspective. Thank you Sir. I found this interesting (especially in light of your commentary on how cancer has been invaded by genomics)
https://www.youtube.com/watch?v=EN58tZ6dspA
I’ll also eagerly await the next installment before fully commenting other than to ask if you are going to address Warburg and the metabolic theory of cancer?
Obviously waiting for the next instalment but (!) have you read The Cancer Code by Jason Fung which proposes the theory that cancer cells are basically a type of reverse evolution ( to behaving the way single celled organisms would). I can’t remember anymore details at the moment but it explained a lot.
Interesting thought about cells switching behaviors as a group emergence.
A very old neurosurgeon told me a story about a glioblastoma clinical trial that he was involved in. He managed to get one of his patients enrolled -- a teenager with an advanced case. The tumor disappeared. People enrolled in that trial had their tumors evaporate - it was an amazing cure. The scientists behind the trial (I believe it was in Boston) of course wanted to bring this cure to market, but the large pharma who owned this special recipe did a cost-benefit calculation and determined that the price would be too high and the (financial) rewards too few to make it worthwhile.
So rather than publicizing this magic recipe for the whole world to benefit from, they simply didn't proceed with bringing it to market.
As for the teenager who was miraculously cured, he got hit by a car a few years later and died. So I guess he had his timeline pretty set in stone.
This neurosurgeon spent the last years of his life draining his own ascites - advanced liver failure - and continued to serve patients until the day of his death.
Yes, the current paradigm is incomplete. Here is why in great detail:
Submolecular Dysregulation Due to Deuterium Accumulation Is the Cause of Cancer.
https://www.townsendletter.com/1b-deuterium-in-water-and-cancer-risk/
https://drpetrad.com/Presentations